As simple as it gets - 5th Ave is the fifth in a series of avenues.
This seems natural for roads laid out on a grid, and torturous when roads either follow irregular natural features, or just swerve around like a drunkard for no good reason.
Front St is on the riverfront; Riverside Dr is along the side of the river; Hayden Run Rd follows the path of Hayden Run.1
Sadly less reliable these days because of the nonsense mentioned later - though one can imagine a highly disappointed person driving on "Resplendent Forest Ln" only to find wall-to-wall freestanding townhomes.
Main St is the main street of the city; people shop on Market St; John St is where people go to solicit...certain services (not actually named for it, but that really was one of the streets used for that purpose in the town where I grew up)
This leads to interesting names when either roads are redirected, or landmark locations change - ex. Cemetery Rd in Hilliard has a noticeable absence of graveyards, but it used to lead to one when it extended further toward the river.
Broad St is wide, because of tree stumps.
I suppose the various Circle Drives that exist could theoretically fit here too, but the one in Hilliard at least barely covers a 90 degree arc.
Dublin-Granville Rd goes between Dublin and Granville; Cleveland Ave might have stretched to Cleveland at one point, although the last I looked it now ended at a strip mall 90 miles away.
I'm sure someone somewhere has figured out what the two most distant points are that are part of a road name like this, but I didn't find it in a quick web search and I'm not sure how to go about figuring it out myself. The one I can think of is Portsmouth-Columbus Rd, the name used by Franklin County for the tiny bit of US Highway 23 on the south side of Columbus that's south of the city limits but north of the county line (Pickaway County, to the south, calls it Columbus Pike).
Britton Pkwy includes what used to be a farm owned by someone with the surname Britton; Blazer Pkwy is named because Paul Blazer founded Ashland, Inc., which has a large office on that road.
Looking at old farm maps in an area like mine can provide a steady stream of delightful moments identifying these sorts of road names.
Pretty sure President Grant didn't live on Grant Ave in Columbus, but you have to sympathize with wanting to honor him
Washington is the most common one of this type across the United States - I wonder who is similarly honored in other countries. At least some other folks are interested in the same question!
Emerald Pkwy isn't particularly green, and doesn't have any deposits of the gems that I'm aware of...but it's in Dublin. Get it? Dublin - and surrounding areas - are full of Irish-sounding street names that are irrelevant to the actual people, surroundings, or history of the region.
Specifically-themed neighborhoods get pretty cheesy - there is nothing whatsoever in a neighborhood in northwest Franklin County, Ohio to justify the street names "Bonanza Ln", "Desert Ln", "Hoss Ln", or "Carson City Ln"
It might shock you to know that there is no mixing of freshwater and seawater on Estuary Ln, or that there's mostly asphalt and concrete on Nature Way.
On principle, one of the worst offenders might be naming anything "Mountain Springs Ct" in central Ohio, one of the flattest areas in this half of the country.